2020 Small World in Motion Competition

Morphing melanoma cells (alpha-Actintin shown in yellow; actin in red)

Dr. Gregory Adams Jr.

National Institutes of Health (NIH)
Bethesda, Maryland, USA
60X (Objective Lens Magnification)

This movie spectacularly shows morphing melanoma cancer cells (in red and yellow). It was captured using spinning disk confocal imaging technology with cancer cells that were transfected with fluorescent fusion proteins and placed on a PDMS BSA coated coverslip (a patterned coverslip designed to control the movement, growth and adhesion of the organism). Dr. Adams studies cancer as a cell biologist and microscopist. Although Dr. Adams says that he partially chose this image to bring to Small World in Motion because of its visual aesthetics, he also felt the subject matter might spark the interest of younger people in science.